Supplemental Figure 2 from T-cell Priming by High-Avidity Neoantigens in Lymph Nodes Augments Adoptive Immunotherapy

Supplemental Figure 2: Pmel-1 T cells bind more tightly to B16KVP compared to B16F10 cells. The immune synapse binding avidity of naïve pmel-1 T cell isolates to B16F10 and B16KVP were assessed via acoustic force microscopy. (A) The force ramp is plotted showing the fraction of T cells bound as the force ramp increases. (B) The area under the curve (AUC) of the fraction of T cells bound during the force ramp from (A) is plotted.