Supplemental Figure 7 from Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency

2026 Open access

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Authors: Juan Martin Barajas, Aaron H. Phillips, Jina Wang, Melvin E. Thomas, Lisett Contreras, Masayuki Umeda, Ryan Hiltenbrand, Elizabeth Caldwell, Michael P. Walsh, Guangchun Song, Lauren Ezzell, Kelly A. Churion
+16 more Tamara Westover, Emily H. Xiong, Chandra Rolle, Jamila Moore, Josi Lott, Sandi Radko-Juettner, Amit Kumar, Wenjie Qi, Beisi Xu, Evangelia K. Papachristou, Clive S. D’Santos, Jing Ma, Burgess B. Freeman, Laura J. Janke, Richard W. Kriwacki, Jeffery M. Klco
DOI: 10.1158/2643-3230.31046980
Cited by: 0

Abstract

Eltanexor treatment in primary human cells. (A–B) Flow cytometry gating and representative plots related to Figures 5C–E. (C) CellTiter-Glo assay in CD34⁺ cells expressing UBTF-TD or UBTF-TD-NES-M. (D) HOXA/B gene expression heatmap after DMSO, dTAG-13, or eltanexor treatment. (E) UpSet plot showing UBTF-TD and XPO1 gene occupancy changes. (F–G) Design and results of colony-forming assays in UBTF-TD PDX cells treated with eltanexor.

Fields of Study & Subjects

Acute Myeloid Leukemia Research Retinoids in leukemia and cellular processes Nuclear Structure and Function

Publication details

Publication date
12 January 2026