Supplementary Figures S1-S6 from ID2 Suppresses Multiple Myeloma Cell Proliferation by Repressing the Activity of the Transcription Factor TCF3

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Authors: Mariateresa Fulciniti, Yao Yao, Tommaso Perini, Jessica Fong Ng, Anaïs Schavgoulidze, Shuhui Deng, Jian Cui, Jessica Encinas, Francesco Ladisa, Ryan M. Young, Charles B. Epstein, Cassandra M. White
+11 more Christopher J. Ott, Annamaria Gullà, Shannon M. Matulis, Adam Samuel Sperling, Eugenio Morelli, Lawrence Boise, Moritz Binder, Raphael Elie Szalat, Mehmet Samur, Kenneth Carl Anderson, Nikhil C. Munshi
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Abstract

Supplementary Figure S1. Discovery of ID2 as a putative tumor suppressor in MM. Supplementary Figure S2. ID2 expression causes cell cycle arrest in MM cells. Supplementary Figure S3. Induced ID2 expression in MM cells is associated with senescence-like features. Supplementary Figure S4. TCF3 is a highly expressed selective dependency in MM cells. Supplementary Figure S5. Depletion of TCF3 phenocopies effects of ID2 overexpression in MM cells. Supplementary Figure S6. The bone marrow milieu has a role in supporting TCF3 activity in MM.

Fields of Study & Subjects

Multiple Myeloma Research and Treatments Wnt/β-catenin signaling in development and cancer Signaling Pathways in Disease

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Publication date
12 January 2026