Supplemental Figure 4 from Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency

2026 Open access

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Authors: Juan Martin Barajas, Aaron H. Phillips, Jina Wang, Melvin E. Thomas, Lisett Contreras, Masayuki Umeda, Ryan Hiltenbrand, Elizabeth Caldwell, Michael P. Walsh, Guangchun Song, Lauren Ezzell, Kelly A. Churion
+16 more Tamara Westover, Emily H. Xiong, Chandra Rolle, Jamila Moore, Josi Lott, Sandi Radko-Juettner, Amit Kumar, Wenjie Qi, Beisi Xu, Evangelia K. Papachristou, Clive S. D’Santos, Jing Ma, Burgess B. Freeman, Laura J. Janke, Richard W. Kriwacki, Jeffery M. Klco
DOI: 10.1158/2643-3230.31046989
Cited by: 0

Abstract

Panel A shows western blot analysis (anti-HA) of cbCD34⁺ cell lysates transduced with various HA-tagged UBTF constructs and vector control. Panel B presents RNA-seq tracks visualized in IGV, highlighting soft-clipped reads that indicate tandem duplications and the expressed cDNA sequences. Panel D-F depict gating strategies and representative flow plots

Fields of Study & Subjects

Acute Myeloid Leukemia Research Acute Lymphoblastic Leukemia research Genomics and Chromatin Dynamics

Publication details

Publication date
12 January 2026