Supplemental Figure 3 from Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency

2026 Open access

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Authors: Juan Martin Barajas, Aaron H. Phillips, Jina Wang, Melvin E. Thomas, Lisett Contreras, Masayuki Umeda, Ryan Hiltenbrand, Elizabeth Caldwell, Michael P. Walsh, Guangchun Song, Lauren Ezzell, Kelly A. Churion
+16 more Tamara Westover, Emily H. Xiong, Chandra Rolle, Jamila Moore, Josi Lott, Sandi Radko-Juettner, Amit Kumar, Wenjie Qi, Beisi Xu, Evangelia K. Papachristou, Clive S. D’Santos, Jing Ma, Burgess B. Freeman, Laura J. Janke, Richard W. Kriwacki, Jeffery M. Klco
DOI: 10.1158/2643-3230.31046992
Cited by: 0

Abstract

Illustrates chromatin protein interactions involving UBTF-TD54–NES-M in K562 cells using qPLEX-RIME. Panel A outlines the experimental design. Panels B and C present volcano plots comparing UBTF-TD54–NES-M to UBTF-WT and NES-M, respectively.

Fields of Study & Subjects

Genomics and Chromatin Dynamics Nuclear Structure and Function Acute Myeloid Leukemia Research

Publication details

Publication date
12 January 2026