Supplementary Figure S14 from PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor–Resistant Chronic Lymphocytic Leukemia

Britten K. Gordon; Elizabeth M. Muhowski; Jyotsana Singh; Janani Ravikrishnan; Arnau Peris-Cuesta; Daisy Diaz Rohena; John R. Sanchez; Shanmugapriya Thangavadivel; Samon Benrashid; Alexander He; Alexander R. Marr; Andrew D. Mitchell; Jazmin M. Urrutia; Shrilekha Misra; Tzung-Huei Lai; Lianbo Yu; Brandi R. Walker; Elizabeth Perry; Sachet Ashok Shukla; Nicole Renee Grieselhuber; Kerry A. Rogers; Rosa Lapalombella; James Stewart Blachly; Adam S. Kittai; Seema Ali Bhat; Nitin Jain; William G. Wierda; John C. Byrd; Michael R. Niesman; Kai Zhang; Deepa Sampath; Jennifer Ann Woyach

doi:10.1158/2643-3230.31047048

Supplementary Figure S14 from PKCβ Inhibitor MS-553 Displays Preclinical Efficacy in Both Treatment-Naïve and BTK Inhibitor–Resistant Chronic Lymphocytic Leukemia

2026 Open access

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Authors: Britten K. Gordon, Elizabeth M. Muhowski, Jyotsana Singh, Janani Ravikrishnan, Arnau Peris-Cuesta, Daisy Diaz Rohena, John R. Sanchez, Shanmugapriya Thangavadivel, Samon Benrashid, Alexander He, Alexander R. Marr, Andrew D. Mitchell

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Jazmin M. Urrutia, Shrilekha Misra, Tzung-Huei Lai, Lianbo Yu, Brandi R. Walker, Elizabeth Perry, Sachet Ashok Shukla, Nicole Renee Grieselhuber, Kerry A. Rogers, Rosa Lapalombella, James Stewart Blachly, Adam S. Kittai, Seema Ali Bhat, Nitin Jain, William G. Wierda, John C. Byrd, Michael R. Niesman, Kai Zhang, Deepa Sampath, Jennifer Ann Woyach

DOI: 10.1158/2643-3230.31047048

Cited by: 0

Abstract

MS-553 inhibits downstream BCR and Wnt/β-catenin signaling in BTKi resistant CLL.

Fields of Study & Subjects

Chronic Lymphocytic Leukemia Research Lymphoma Diagnosis and Treatment Acute Lymphoblastic Leukemia research

Publication details

Publication date: 12 January 2026