Figure 7 from CD70-Targeting CAR NK Cells Overcome BCMA Downregulation and Improve Survival in High-risk Multiple Myeloma Models

CAR27/IL-15 NK cells display comparable anti-multiple myeloma activity to CAR27/IL-15 T cells. A, Cytotoxicity of NT NK, CAR27/IL-15 NK, NT T, and CAR27/IL-15 T cells against MM.1S tumor cells was assessed using an Incucyte assay. Bar graph (right) shows AUC analysis. B, NSG mice were injected with MM.1S tumor cells on day −3 and treated on day 0 with CAR27/IL-15 NK cells or CAR27/IL-15 T cells or left untreated (tumor alone). C, Tumor burden was monitored by BLI through day 34. D, BLI signal for individual mice plotted over time. E, Mouse body weight was measured during the study as an indicator of treatment tolerability. Data are represented as mean ± SD. Data for the AUC graph are represented as mean ± SEM. The P values were determined by one-way ANOVA with Tukey multiple comparison (A). ***, P ≤ 0.001.