Seeing Is Believing: IEC-HS after CAR T Cells
Abstract
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) is a complication seen in patients receiving chimeric antigen receptor (CAR) T cells, more frequently in those with CD22- or BCMA-targeted constructs compared with CD19. While associated with higher CAR T-cell expansion and a unique cytokine profile, the constellation of three cytokines (IFNγ, IL10, and IL1RA) correlated most strongly with IEC-HS severity and may help guide preemptive interventions. See related article by Srinagesh et al., p. 225.
Fields of Study & Subjects
CAR-T cell therapy research
Autoimmune and Inflammatory Disorders Research
Immunodeficiency and Autoimmune Disorders
Publication details
- Journal / source
- Blood Cancer Discovery
- Volume
- 7
- Issue
- 2
- Pages
- 163–165
- Publication date
- 4 February 2026
- Language
- EN