A Triumvirate of Transformation: Oncogene, Ontogeny, and Plasticity

Blood Cancer Discovery 2026

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Authors: Bisi Miao, Jian Xu
DOI: 10.1158/2643-3230.bcd-26-0006
Cited by: 0
References: 8

Abstract

Cancer cells display extensive heterogeneity that influences therapy response and clinical outcome, yet the underlying mechanisms remain incompletely understood. Recent studies reveal that the developmental state and molecular plasticity of target cells, together with genetic lesions, drive cellular transformation, disease heterogeneity, and treatment response in hematologic malignancies. See related article by Hartmann et al., p. 306 (9) See related article by Wang et al. (8).

Fields of Study & Subjects

Acute Myeloid Leukemia Research Acute Lymphoblastic Leukemia research Cancer Genomics and Diagnostics

Publication details

Journal / source
Blood Cancer Discovery
Volume
7
Issue
2
Pages
168–170
Publication date
4 February 2026
Language
EN