Outstanding Questions to Understand and Target Splicing Factor–Mutant Blood Cancers
Abstract
Mutations in genes encoding RNA splicing factors are common in patients with myeloid malignancies and chronic lymphocytic leukemia. In this commentary, we discuss key unanswered questions on the causal role of these mutations in blood cancers and precursor conditions as well as efforts to develop therapies targeting these high-frequency neomorphic mutations.
Fields of Study & Subjects
RNA Research and Splicing
Acute Myeloid Leukemia Research
Nuclear Structure and Function
Publication details
- Journal / source
- Blood Cancer Discovery
- Publisher
- American Association for Cancer Research (AACR)
- Volume
- 7
- Issue
- 3
- Pages
- 348–352
- Publication date
- 21 April 2026
- Language
- EN