Figure 3 from Copy-Number Aberrations in Circulating Tumor DNA Enable Diagnosis and Risk Stratification of Pediatric Neuroblastic Tumors

CIN in plasma ctDNA predicts the high-risk group in patients with pNT. A, A Heatmap of segmental alterations in ctDNA from patients with pNT. Patient information is shown at the bottom of the panel. Scale bar represents copy-number Z-score of each segment. B, Representative genome-wide copy-number variation in a healthy child (top) and a patient with pNT (bottom). C, ROC curves illustrated the diagnostic performance of chromosomal aberrations in distinguishing between healthy controls and high-risk pNTs. AUC is shown for each chromosomal aberration. D, HRD score in different risk groups of pNTs. Boxes indicate the median (horizontal line), 25th percentile, and 75th percentile; whiskers indicate distances from the largest and smallest value to each end of the box that are within 1.5 × box length. Values were compared with the Wilcoxon test. **, P < 0.01; ****, P < 0.0001; ns, not significant. Amp, amplified; GN, ganglioneuroma; GNB, ganglioneuroblastoma; HC, healthy control; NB, neuroblastoma; non-amp, nonamplified.