Figure 2 from Copy-Number Aberrations in Circulating Tumor DNA Enable Diagnosis and Risk Stratification of Pediatric Neuroblastic Tumors

CNA burden in plasma ctDNA enables diagnosis and risk stratification of pNTs. A–E, TFx in various clinicopathologic groups of pNTs. Boxes indicate the median (horizontal line), 25th percentile, and 75th percentile; whiskers indicate distances from the largest and smallest value to each end of the box that are within 1.5 × box length. Values were compared with the Wilcoxon test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant. F–H, ROC curves of the pNT-UCAD model for risk-based stratification analysis. The TFx cutoff was defined by maximizing the Youden index (sensitivity + specificity − 1) using the pROC R package. Amp, amplified; GN, ganglioneuroma; GNB, ganglioneuroblastoma; HC, healthy control; NB, neuroblastoma; non-amp, nonamplified.