Figure 6 from Cell State Transitions Drive the Evolution of Disease Progression in B-Lymphoblastic Leukemia

Matched samples from patients at diagnosis and relapse. A, Markov transition rate chord diagrams for matched patients at diagnosis (top) and relapse (bottom), ordered from left to right by time to relapse. B, Biplot showing the change in each transition parameter value at diagnosis and relapse (left to right). Note that all 16 transition parameters are not significantly different, indicating no clear pattern of change between diagnosis and relapse across our cohort of matched samples. C, Markov transition rate chord diagrams for matched patients at diagnosis (top) and remission (bottom). D, Biplot showing the change in each transition parameter value at diagnosis and remission (left to right). Significant changes are observed in all transitions back into compartments 1 and 3 (CD34+/CD38− and CD34−/CD38+, respectively). Numbers in A and B indicate sample ID, corresponding to the Morpheus diagram in Fig. 2I. *, Statistical significance using two-sample t test with significance value of 0.05.