Figure 4 from Cell State Transitions Drive the Evolution of Disease Progression in B-Lymphoblastic Leukemia

Samples from patients with leukemia. A, Chord diagram illustrating the mean transition matrix across all patients, for all PB (left) and BM samples (right), repeated for BCR::ABL1-positive (top) and BCR::ABL1-negative (bottom) patients. BCR::ABL1-positive samples are typically associated with high CD34+/CD38− self-renewal (M11) and high CD34+/CD38− incoming rates (M21, M21, and M31). BCR::ABL1-negative patient samples have low CD34+/CD38− self-renewal rates (M11) and either high CD34+/CD38+ (M12, M32, and M42) or high CD34−/CD38+ (M13, M23, and M43) incoming rates. B, Matched samples from PB and BM reach good agreement in transition rates for both BCR::ABL1-positive or -negative samples. Numbers indicate sample ID, corresponding to the Morpheus diagram in Fig. 2I.