Figure 3 from Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis

Immune cell features driving heterogeneity in ovarian cancer. A, Correlations between expression of genes in the MHC-II antigen presentation pathway and the density of proliferating tumor cells, CD8+ T cells, and macrophages in the TC and IM. All values plotted on a log scale. The coloring of points in this plot follows the scheme of the other panels. B, Scatter plots showing the relationship between the density of proliferating tumor cells and the expression of a group of collagen-related genes that were the highest weighted in MOFA latent variable 7 (CCN2, COL1A1, CCN1, DCN, COL1A2, COL12A1, COL5A1, EGR1, COL3A1, and COL6A3). C, Plot of T-cell inhibitor density and IM immune cell density. Dashed rectangles indicate groups of patients discussed in the main text. D, Beeswarm plot of the difference in density of CD8+ T cells and PD-L1+ tumor cells. A positive value means a higher density of PD-L1+ tumor cells than CD8+ T cells and vice versa.