Figure 2 from Characterization of the Immunogenomic Landscape of Ovarian Cancer Uncovers a Distinct Subset of Endometroid Tumors Associated with High CST2 Expression and a Favorable Prognosis

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Authors: James Boyle, Jan Maciej Zaucha, Felicia Ng, Andreas Spitzmüller, Miljenka Vuko, Felix J. Segerer, Monica Azqueta-Gavaldon, Marco Testori, Amelia Raymond, Barrett R. B. Nuttall, Andrea Ennio Storti, Sakshi Gulati
+9 more Shaan Gill, Michael J. Surace, Paola Marco‐Casanova, Emma V. Jones, Ben S. Sidders, Jorge Sergio Reis-Filho, Maurizio Scaltriti, Anita Semertzidou, Helen K. Angell
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Abstract

Beeswarm plots of the MOFA latent variables in each subtype. Variable 1: Density of PD-1 and PD-L1 positivity in TC and IM; variable 2: expression of MHC-II antigen presentation pathway genes; variable 3: density of CD8+ and CD68+ cells in IM; variable 4: mutually exclusive mutations in tumors; variable 5: difference between density of CD8+ T cells and PD-L1+ tumor cells across tumor; variable 6: expression of specific chemokine-related genes; variable 7: expression of specific collagen-related genes; variable 8: expression of CST2; variable 9: expression of specific interferon-related genes; and variable 10: expression of COL11A1.

Fields of Study & Subjects

Ovarian cancer diagnosis and treatment Cancer Immunotherapy and Biomarkers Endometrial and Cervical Cancer Treatments

Publication details

Publication date
28 January 2026