Figure 5 from Novel Syngeneic Cell Lines for Studying High-Risk BRAFV600E-Driven Colorectal Cancer In Vivo

2026 Open access

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Authors: Jasmin Traichel, Ariane Metzger, Maria Walz, Reinhild Feuerstein, Nadine Wohlfeil, Patrick Metzger, Lisa Marx, Célia Asdih, Agnes Lindenthal, Alina Seger, Jule Schrimpf, Luigi L. Nardella
+7 more Silke Kowar, Ian J. Frew, Sebastian Halbach, Rebecca Kesselring, Melanie Boerries, Ricarda Griffin, Tilman Brummer
DOI: 10.1158/2767-9764.31343755
Cited by: 0

Abstract

Tumors formed by the three NaJa lines exhibit differences in their TMEs. Representative photos of IHC staining in NaJa-induced liver tumors with indicated antibodies, CD8a, CD8+ T cells, F4/80, macrophages, Col1a1, collagen type 1 alpha 1 chain, FOXP3, regulatory T cells, CD19, B cells. Scale bar (FOXP3), 20 μm, scale bar (rest), 50 μm. F4/80 and PD-L2 staining were performed on 3-μm-thick serial cuts to allow comparison of staining patterns in adjacent tumor regions.

Fields of Study & Subjects

Colorectal Cancer Treatments and Studies Cancer Immunotherapy and Biomarkers Genetic factors in colorectal cancer

Publication details

Publication date
16 February 2026
Language
EN