Figure 1 from ZSTK3744, a Novel Aryl Hydrocarbon Receptor Agonist, Exhibits Efficacy against Chemotherapy-Resistant Triple-Negative Breast Cancer

Establishment of chemotherapy-resistant TNBC cells. MM468/AR and MM468/PR cell lines were established. Parental MM468 cells, along with the MM468/AR (A) or MM468/PR (B) cells, were treated with adriamycin, paclitaxel, or eribulin at the indicated concentrations for 72 hours. Cell viability was assessed using the Cell Counting Kit-8 assay, and the results are presented as mean ± SD of quadruplicate experiments. Statistical analysis was performed using the Mann–Whitney U test (*, P < 0.05 vs. parental MM468). Parental MM468 cells are presented in blue, whereas chemotherapy-resistant MM468 cells (MM468/AR and MM468/PR) are presented in orange. wt, wild type.