Supplementary Figure 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

Annie Wai Yeeng Chai; Yee Hua Tan; Shiyin Ooi; Pei San Yee; Shi Mun Yee; Howard W. Lightfoot; Syd Barthorpe; Mathew J. Garnett; Sok Ching Cheong

doi:10.1158/2767-9764.31762067

Supplementary Figure 5 from High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis

2026 Open access

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Authors: Annie Wai Yeeng Chai, Yee Hua Tan, Shiyin Ooi, Pei San Yee, Shi Mun Yee, Howard W. Lightfoot, Syd Barthorpe, Mathew J. Garnett, Sok Ching Cheong

DOI: 10.1158/2767-9764.31762067

Cited by: 0

Abstract

Necroptosis is activated in the absent of CASP8 upon AZD5582 treatment as shown by induction of p-MLKL.

Fields of Study & Subjects

Cell death mechanisms and regulation Head and Neck Cancer Studies NF-κB Signaling Pathways

Publication details

Publication date: 16 March 2026
Language: EN