Association between Vitamin B12 Levels and Colon Cancer Survival: A Global Network Study

Cancer Research Communications 2026 Open access

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Authors: Bruce Chang-Gu, George Golovko, Anthony P. D’Andrea, Kamil Khanipov
DOI: 10.1158/2767-9764.crc-25-0557
Cited by: 1
References: 31

Abstract

Recent studies have reported a link between elevated B12 levels and increased incidence of malignancies. In this study, we compare the association between B12 levels and adverse outcomes in colon cancer, including metastases and mortality. A globally federated multi-institutional database identified patients with colon cancer who had at least one B12 measurement within 1 year of diagnosis. Patients were stratified by B12 status (normal: 300-1,000, elevated: >1,000, and low:

Fields of Study & Subjects

Folate and B Vitamins Research Ferroptosis and cancer prognosis Cancer Research and Treatments

Publication details

Journal / source
Cancer Research Communications
Publisher
American Association for Cancer Research (AACR)
Volume
6
Issue
2
Pages
302–309
Publication date
7 January 2026
Language
EN