Sickle Cell Crisis-Induced Painless Bilateral Orbital Bone Infarction: A Case Report

Case Reports in Ophthalmology 2026 Open access

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Authors: Luke B Farson, Marina Shenouda, Agni Kakouri, Ashkan Kashanchi, Clark Sitton, Timothy James McCulley, Ying Chen
DOI: 10.1159/000550138
Cited by: 1
References: 13

Abstract

Introduction: Sickle cell disease is associated with painful vaso-occlusive crises, bone infarction, avascular necrosis, and osteomyelitis. Sickle cell orbitopathy is a rare manifestation with signs similar to periorbital cellulitis and has subtle radiologic features. Case Presentation: We report a case of a five-year-old girl with sickle cell who presented with bilateral orbital infarctions and subperiosteal hematomas, notably without periorbital pain, and was treated with antibiotics and steroids. Conclusion: Physicians should be aware of this rare manifestation, especially in the pediatric population, as it can affect subsequent management.

Fields of Study & Subjects

Hemoglobinopathies and Related Disorders Ophthalmology and Eye Disorders Facial Trauma and Fracture Management

Publication details

Journal / source
Case Reports in Ophthalmology
Publisher
S. Karger AG
Volume
17
Issue
1
Pages
156–161
Publication date
19 January 2026
Language
EN