Salivary Testosterone Concentration and Cognitive Impairment among Japanese Older Adults in the Toon Health Study

Neuroepidemiology 2026 Open access

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Authors: Juna Kamijima, Ai Ikeda, Hadrien Charvat, Koutatsu Maruyama, Kiyohide Tomooka, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa, Madoka Tatsukawa, Miyuki Yoshida, Akiko Kooka, Tamami Shiba
+5 more Tomoko Nishiyama, Kazumi Fujimura, Keiko Suyama, Isao Saito, Tomomi Tanigawa
DOI: 10.1159/000550694
Cited by: 0
References: 54

Abstract

INTRODUCTION: As the number of people with mild cognitive impairment (MCI) increases, modifiable risk factors, such as stress and an unhealthy lifestyle, and preventative measures are gaining interest. However, evidence for an association between potential biomarkers of such risk factors and MCI is limited. The study aimed to investigate the association between the salivary testosterone concentration and MCI in Japanese community-dwelling older adults. METHODS: This cross-sectional study involved 359 participants (159 men and 200 women) aged 60 years and over. MCI was evaluated using the Japanese version of the Montreal Cognitive Assessment; a score

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Hormonal and reproductive studies Menopause: Health Impacts and Treatments

Publication details

Journal / source
Neuroepidemiology
Pages
1–11
Publication date
5 March 2026
Language
EN