Urinary Biomarker Profiles Define Divergent Pathways in Albuminuric and Non-Albuminuric Diabetic Kidney Disease

Kidney Diseases 2026 Open access

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Authors: Yunus Kaygusuz, Deniz Aral Özbek, Arda Erdut, Rukiye Abanoz, Melek Günindi Korkut, Murat Ozdede, Oğuz Abdullah Uyaroğlu, Füsun Özmen, Hacı Hasan Yeter, Tolga Yıldırım, Şeref Rahmi Yilmaz, Mustafa Arıcı
+2 more Yunus Emre Erdem, Bülent Altun
DOI: 10.1159/000550855
Cited by: 1
References: 52

Abstract

Introduction: Diabetic kidney disease (DKD) presents with distinct phenotypes, including albuminuric (ADKD) and non-albuminuric DKD (NADKD), which are not fully distinguished by conventional clinical markers. This study aimed to evaluate urinary biomarkers indicative of nephron injury – nephrin, epidermal growth factor (EGF), vascular cell adhesion molecule-1 (VCAM-1), interleukin-18 (IL-18), and Rac-1 (Ras-related C3 botulinum toxin substrate) across various DKD phenotypes. Methods: In this cross-sectional study, 211 patients with type 2 diabetes mellitus were categorized into four groups based on estimated glomerular filtration rate (eGFR ≥ or

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Renal Diseases and Glomerulopathies Acute Kidney Injury Research

Publication details

Journal / source
Kidney Diseases
Publisher
S. Karger AG
Volume
12
Issue
1
Pages
330–345
Publication date
12 February 2026
Language
EN