Age-Related Phenotypic Divergence in Nonsteroidal Anti-Inflammatory Drug Hypersensitivity: Clinical and Comorbidity Correlates

International Archives of Allergy and Immunology 2026

View at publisher
Authors: Emrah Harman, Fatih Çölkesen, Mehmet Emin Gerek, Ferhat Sağun, Seçim Kolak, Şükran Aslan Savaş, İsmail Yiğitdöl, Ümmügülsüm Yılmaz Ergün, Şevket Arslana
DOI: 10.1159/000551405
Cited by: 0
References: 24

Abstract

INTRODUCTION: Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity is a heterogeneous condition with diverse clinical phenotypes. Although age-related changes in immune and inflammatory pathways have been proposed, systematic evaluations of age-associated phenotypic differences remain limited. METHODS: Between 2019 and 2025, 1,363 patients evaluated for suspected drug hypersensitivity were screened, and 484 adults with clinically defined NSAID hypersensitivity were retrospectively analyzed. Patients were categorized as early-onset (

Fields of Study & Subjects

Drug-Induced Adverse Reactions Food Allergy and Anaphylaxis Research Pharmacovigilance and Adverse Drug Reactions

Publication details

Journal / source
International Archives of Allergy and Immunology
Pages
1–10
Publication date
12 March 2026
Language
EN