Prolonged Low-Dose Paracetamol Prophylaxis Accelerates Ductal Closure in Extremely Preterm Neonates: A Randomized Trial

Neonatology 2026 Open access

Read full text
Authors: Tiina Ukkonen, Eveliina Ronkainen, Aliisa Laitala, Timo Saarela, Mikko Hallman, Outi Aikio
DOI: 10.1159/000552204
Cited by: 1
References: 30

Abstract

INTRODUCTION: Patent ductus arteriosus (PDA) is associated with increased morbidities and mortality in extremely preterm infants. The biological effect of acetaminophen on the closure of ductus has been shown; however, the effective and safe dosage for early treatment of the most preterm infants remains unknown. METHODS: In a single-centre, randomised, controlled, double-blind, phase II pilot trial, extremely low gestational age (ELGA,

Fields of Study & Subjects

Cardiovascular Conditions and Treatments Congenital Heart Disease Studies Animal health and immunology

Publication details

Journal / source
Neonatology
Publisher
S. Karger AG
Pages
1–10
Publication date
14 May 2026
Language
EN