Prognostic Value of Baseline and Early Proteinuria Changes in IgA Nephropathy: A US Cohort Study
Abstract
Introduction: Proteinuria is a key marker in IgA nephropathy (IgAN). However, long-term thresholds and significance of early changes in proteinuria remains unclear in US populations. Methods: , sustained >40% eGFR decline, initiation of dialysis, or all-cause mortality) was evaluated. Associations with baseline TAP and changes in TAP at first-year were evaluated using Kaplan-Meier analysis and multivariable Cox proportional hazard models. Results: Out of 745 patients (mean age 43.5 [±16] years, 58% male, 68% White), a composite outcome occurred in 175 (23.5%) of patients over a median follow-up of 5.4 years (IQR: 3.2-7.2). Survival analysis showed 13.8% of patients with TAP
Fields of Study & Subjects
Renal Diseases and Glomerulopathies
Chronic Kidney Disease and Diabetes
Renal Transplantation Outcomes and Treatments
Publication details
- Journal / source
- Glomerular Diseases
- Publisher
- S. Karger AG
- Volume
- 6
- Issue
- 1
- Pages
- 249–259
- Publication date
- 8 June 2026
- Language
- EN