Evolution and Prognostic Value of Right Ventricular to Pulmonary Artery Coupling During Guideline-Directed Medical Therapy Up-Titration

Circulation Heart Failure 2026

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Authors: Paul Le Dantec, Théo Liets, Julie Burdeau, Quentin Laissac, Camilia Hayoun, I. Jaballah, Samia Benchekroun, Attoumane-Abdou Cheikh, Corentin Chaumont, Frédéric Anselme, Éric Durand, H. Eltchaninoff
+1 more Charles Fauvel
DOI: 10.1161/circheartfailure.125.012980
Cited by: 3
References: 32

Abstract

BACKGROUND: Up-titration of guideline-directed medical therapy (GDMT) is known to enhance left ventricular function in heart failure (HF) with reduced ejection fraction. However, data regarding its effect on right ventricular (RV) function remain sparse. We aimed to assess the impact of GDMT up-titration on the RV, especially RV to pulmonary artery coupling, and its prognostic value in these patients. METHODS: All consecutive patients (n=291) with left ventricular ejection fraction

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Cardiovascular Function and Risk Factors Heart Failure Treatment and Management

Publication details

Journal / source
Circulation Heart Failure
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
19
Issue
4
Pages
e012980–e012980
Publication date
7 January 2026
Language
EN