Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study

Circulation Heart Failure 2026 Open access

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Authors: Justin Basile Echouffo-Tcheugui, Chiadi E. Ndumele, JINGSHA CHEN, MARY R. ROONEY, Keenan A. Walker, Pascal Schlosser, Kuni Matsushita, Morgan E. Grams, C M B Ballantyne, Ron Hoogeveen, Eric Boerwinkle, Bing Yu
+10 more Amil M. Shah, Ruth F. Dubin, Rajat Deo, Yue Ren, Jerome I. Rotter, Kent D. Taylor, Wendy Post, Peter R. Ganz, Elizabeth Selvin, Josef Coresh
DOI: 10.1161/circheartfailure.125.013171
Cited by: 1
References: 32

Abstract

BACKGROUND: To investigate the proteomic signatures of heart failure (HF) in diabetes. The underlying mechanisms of the elevated risk of HF in diabetes are unknown. METHODS: In 10 189 ARIC study (Atherosclerosis Risk in Communities) participants free of HF (mean age 57±7 years, 56% women, 22% Black adults, 14% with diabetes), we conducted discovery and internal validation for the associations of 4955 plasma proteins with HF by diabetes status. We performed (1) Cox regression to identify proteins associated with HF by diabetes status, (2) external validation in the MESA study (Multi-Ethnic Study of Atherosclerosis, n=5233, 633 with diabetes), and (3) pathway analyses for identified proteins. RESULTS:

Fields of Study & Subjects

Advanced Proteomics Techniques and Applications GDF15 and Related Biomarkers Adipokines Inflammation and Metabolic Diseases

Publication details

Journal / source
Circulation Heart Failure
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
19
Issue
3
Pages
e013171–e013171
Publication date
22 January 2026
Language
EN