Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension

Circulation Heart Failure 2026 Open access

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Authors: Mona Alotaibi, Amber B. Tang, Nancy Sun, Ian Gurholt, Emma Yuguchi, Kari Roberts, Ioana R. Preston, Rod Warburton, Jason X.‐J. Yuan, Nick H. Kim, Stephen Y. Chan, Mohit Jain
+2 more Susan C. Cheng, Nicholas S. Hill
DOI: 10.1161/circheartfailure.125.014073
Cited by: 1
References: 54

Abstract

BACKGROUND: Pulmonary hypertension (PH) due to left-sided heart disease (Group 2 PH) is the most common type of PH and comprises 2 subtypes with distinct clinical profiles and outcomes: isolated postcapillary PH and combined pre- and postcapillary PH (Cpc-PH). Bioactive lipid derivatives may underlie these divergent subphenotypes. This study aimed to investigate the molecular heterogeneity underlying Group 2 PH subtypes and identify shared pathways between Cpc-PH and pulmonary arterial hypertension (PAH). METHODS: In a cross-sectional study, we profiled plasma bioactive lipids using liquid chromatography-mass spectrometry in 128 patients with isolated postcapillary PH (n=21), Cpc-PH (n=69), or PAH (n=38), as well as in plasma samples from animal models of severe PH. RESULTS:

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Eicosanoids and Hypertension Pharmacology Fatty Acid Research and Health

Publication details

Journal / source
Circulation Heart Failure
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
19
Issue
10
Pages
e014073–e014073
Publication date
10 September 2026
Language
EN