Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial

Circulation Cardiovascular Imaging 2026 Open access

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Authors: Jan Michael Brendel, T. Mayrhofer, Júlia Karády, Márton Kolossváry, N. Kerkovits, I. Langenbach, Matthias Jung, Michelle D. Kelsey, M. Langenbach, N. J. Pagidipati, Svati Shah, Michael T. Lu
+3 more Maros Ferencik, Pamela S. Douglas, Borek Foldyna
DOI: 10.1161/circimaging.125.019011
Cited by: 4
References: 33

Abstract

BACKGROUND: Quantitative coronary plaque measures differ in prognostic value between women and men. It remains unclear whether cardiovascular risk increases proportionally with plaque extent in both sexes. We aimed to compare cardiovascular risk trajectories across quantitative coronary plaque measures in women and men with stable chest pain. METHODS: We analyzed data from the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) coronary computed tomography angiography arm, quantifying total coronary plaque volume and burden (plaque burden [PB]; % vessel volume), including calcified, noncalcified, and low-attenuation components. Associations with major adverse cardiovascular events (death, myocardial infarction, or unstable angina hospitalization) were assessed using sex-stratified spline Cox models over a median 26 months (interquartile range, 18-34). RESULTS:

Fields of Study & Subjects

Acute Myocardial Infarction Research Cardiac Imaging and Diagnostics Coronary Interventions and Diagnostics

Publication details

Journal / source
Circulation Cardiovascular Imaging
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
19
Issue
3
Pages
e019011–e019011
Publication date
23 February 2026
Language
EN