Impact of Coronary Diameter Stenosis and Proximal Lesion Location on Outcomes Following PCI in Patients Undergoing TAVI: Prespecified NOTION-3 Substudy

Circulation Cardiovascular Interventions 2026

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Authors: Matti Riihiniemi, Jasmine Melissa Madsen, Jarkko Piuhola, Matti J. Niemelä, Charlotte Glinge, Reza Jabbari, Muhammad Sabbah, Karsten Tange Veien, Phillip Michael Freeman, Rickard Linder, Dan Ioanes, Christian Juhl Terkelsen
+18 more Olli A. Kajander, Sasha M. Koul, Mikko Savontaus, Pasi P. Karjalainen, Evald Høj Christiansen, Ashkan Eftekhari, Lene Holmvang, Rikke Sørensen, Julia Ellert‐Gregersen, Andreas Rück, Oskar Angerås, Gintautas Bieliauskas, Troels Højsgaard Jørgensen, Juhani M. Junttila, Lars Søndergaard, Ole De Backer, Thomas Engstrøm, Jacob Thomsen Lønborg
DOI: 10.1161/circinterventions.125.016286
Cited by: 1
References: 30

Abstract

BACKGROUND: Optimal treatment of coronary artery disease in patients undergoing transcatheter aortic valve implantation remains debated. Here, our aim was to analyze the impact of the diameter and location of coronary stenosis on outcomes in patients undergoing percutaneous coronary intervention (PCI) with transcatheter aortic valve implantation. METHODS: This study was a prespecified subanalysis of the NOTION-3 trial (Nordic Aortic Valve Intervention), which randomized patients with severe symptomatic aortic stenosis and physiologically significant stable coronary artery disease to receive either PCI or conservative treatment of coronary artery disease with transcatheter aortic valve implantation. In this substudy, patients were stratified according to diameter stenosis (

Fields of Study & Subjects

Cardiac Valve Diseases and Treatments Coronary Interventions and Diagnostics Cardiovascular Function and Risk Factors

Publication details

Journal / source
Circulation Cardiovascular Interventions
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
19
Issue
9
Pages
e016286–e016286
Publication date
24 July 2026
Language
EN