Multivalve Involvement in Aortic Stenosis: Insights From a Narrative Review

Circulation 2026

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Authors: Quentin Battistolo, Marisa Avvedimento, Patrice Guerin, Pierre Yves Turgeon, Mathieu Bernier, Mack Mj, Patrick O’Gara, J. Rodés-Cabau
DOI: 10.1161/circulationaha.125.075978
Cited by: 2
References: 116

Abstract

Many patients with severe aortic stenosis present with concomitant multivalvular heart disease. The management of this condition remains challenging and requires a multidisciplinary approach that integrates clinical, hemodynamic, and multimodality imaging data to define the most effective and durable treatment strategy. Although randomized evidence to guide treatment decisions in this setting is limited, percutaneous interventions to address additional valvular lesions are being increasingly adopted. This review provides an overview of the pathophysiology of valvular diseases commonly associated with severe aortic stenosis, highlighting their prognostic implications after surgical or transcatheter treatment and their impact on risk stratification and therapeutic management.

Fields of Study & Subjects

Cardiac Valve Diseases and Treatments Williams Syndrome Research Congenital Heart Disease Studies

Publication details

Journal / source
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
153
Issue
2
Pages
115–131
Publication date
12 January 2026
Language
EN