Incremental Prognostic Value of Subendocardial Myocardial Flow Reserve in Patients With Normal Perfusion

Circulation 2026 Open access

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Authors: Diana M. Lopez, Jenifer M. Brown, Sanjay Divakaran, Daniel M. Huck, Brittany N. Weber, Jon M. Hainer, Sylvain Carre, M A R K Lemley, Giselle Ramirez, Aakash Dhananjay Shanbhag, Paul Kavanagh, Joanna X. Liang
+26 more Ron Blankstein, Sharmila Dorbala, Damini Dey, Stacey Knight, Viet T. Le, Steve M. Mason, Samuel Wopperer, Panithaya Chareonthaitawee, Thomas L. Rosamond, Jacek Kwieciński, Robert J.H. Miller, Leandro Slipczuk, Mark I. Travin, Erick Alexanderson, Isabel Carvajal-Juárez, René R S Packard, Mouaz Al-Mallah, Andrew Jeffrey Einstein, Attila Feher, Wanda Acampa, Rupa Sanghani, Ronny R. Buechel, Robert A. deKemp, Daniel S. Berman, Piotr J. Slomka, Marcelo F. Di Carli
DOI: 10.1161/circulationaha.125.078816
Cited by: 1
References: 25

Abstract

BACKGROUND: Although the prognostic utility of positron emission tomography (PET) myocardial flow reserve (MFR) is well established, emerging data suggest that reduced subendocardial flows also predict adverse outcomes. However, the incremental value of subendocardial MFR (MFR SE ) beyond transmural MFR (MFR TM ) remains unclear. METHODS: We studied patients in a multicenter PET registry with normal perfusion on stress/rest Rb-82 PET, excluding those with a previous history of coronary artery bypass surgery, heart transplantation, or left ventricular ejection fraction

Fields of Study & Subjects

Cardiac Imaging and Diagnostics Cardiovascular Function and Risk Factors Pulmonary Hypertension Research and Treatments

Publication details

Journal / source
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
154
Issue
3
Pages
212–222
Publication date
4 June 2026
Language
EN