Frailty Index Offers Greater Discrimination Than Age for Optimal Blood Pressure Targets: A Pooled Analysis of Two Randomized Trials

Hypertension 2026

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Authors: Yizhen Lyu, Wenming Bian, Yezhou Liu, Yetong Liu, Jiaheng Zhang, Ziang Song, Yamei Liu, Tao Chen, Chao Li
DOI: 10.1161/hypertensionaha.125.26397
Cited by: 3
References: 37

Abstract

BACKGROUND: Contemporary hypertension guidelines emphasize individualized blood pressure (BP) management, often incorporating age; yet chronological age alone may be insufficient to guide optimal treatment. The frailty index offers a multidimensional measure of biological aging and may better guide BP management. METHODS: We pooled participant-level data from SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes). The frailty index was calculated using a 31-item Rockwood cumulative-deficit model, with frailty defined as a frailty index >0.21. Participants were also categorized by age (

Fields of Study & Subjects

Frailty in Older Adults Blood Pressure and Hypertension Studies Nutrition and Health in Aging

Publication details

Journal / source
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
83
Issue
6
Pages
e26397–e26397
Publication date
6 March 2026
Language
EN