Sex‐Related Differences in Clinical Profile, Management, and Outcomes of Patients With Type A and B Acute Aortic Dissection: Observations From IRAD

Journal of the American Heart Association 2026 Open access

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Authors: Elizabeth Jackson, Andreina Carbone, Sherene Shalhub, Chih‐Wen Pai, Marek Ehrlich, Toru Suzuki, G. Chad Hughes, Anil Bhan, Rumi Faizer, Antonio Cittadini, Alan Braverman, Eric M. Isselbacher
+3 more Kim A. Eagle, Christoph Nienaber, Eduardo Bossone
DOI: 10.1161/jaha.124.037506
Cited by: 3
References: 17

Abstract

Background Available data about sex differences in patients with acute aortic dissection (AAD) are scant and conflicting. The aim of this study is to assess sex‐related differences in clinical characteristics, presentation, diagnostic findings, management, and outcomes among patients with type A (TA‐AAD) and type B AAD (TB‐AAD). Methods Data about 11 586 patients enrolled in the IRAD (International Registry of Acute Aortic Dissection) from 1996 to 2022, were analyzed; 7819 (67.5%) experienced TA‐AAD and 3867 (33.0%) TB‐AAD. Men and women were compared with regard to diagnosis, treatment, and in‐hospital and long‐term survival. Results One third of patients were women (TA‐AAD, 34.4%; and TB‐AAD, 34.5%). Women were older than men for both types of AAD. The median time from hospital admission to diagnosis was longer in women for both TA‐AAD and TB‐AAD ( P

Fields of Study & Subjects

Aortic Disease and Treatment Approaches Aortic aneurysm repair treatments Connective tissue disorders research

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
5
Pages
e037506–e037506
Publication date
26 February 2026
Language
EN