Heart Failure Risk in Patients With Systemic Autoimmune Inflammatory Diseases
Abstract
Background Cardiac disease, including heart failure (HF), is a significant cause of morbidity and mortality for patients with systemic autoimmune inflammatory diseases (SAIDs). We sought to describe HF risk among patients with SAIDs and to investigate associations between cardiovascular drug use and incident HF. Methods We conducted a retrospective cohort study of electronic health records of 182 795 adult patients with SAIDs including systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease, and HIV from 2000 to 2020 and track their risks of new‐onset incident HF in a large multidisciplinary health care institution. Results Systemic sclerosis (adjusted hazard ratio [aHR], 2.81 [95% CI, 2.57–3.08]; P
Fields of Study & Subjects
Rheumatoid Arthritis Research and Therapies
Systemic Sclerosis and Related Diseases
Systemic Lupus Erythematosus Research
Publication details
- Journal / source
- Journal of the American Heart Association
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 15
- Issue
- 2
- Pages
- e039155–e039155
- Publication date
- 14 January 2026
- Language
- EN