Associations Between Sustained Methamphetamine/Amphetamine Use and Left Ventricular Dysfunction in a Cohort of Women Living With and Without HIV

Journal of the American Heart Association 2026 Open access

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Authors: Elise D. Riley, Yifei Ma, Kathérine C. Wu, Sanyog G. Shitole, Torsten B. Neilands, Claudia Martinez, Denise C Vidot, Adam W Carrico, Aruna Chandran, Carlos J. Rodriguez, Jason Lazar, Daniel Merenstein
+5 more Michelle Floris‐Moore, Antonina Foster, Kathleen M. Weber, Phyllis C. Tien, Jorge R. Kizer
DOI: 10.1161/jaha.125.041888
Cited by: 2
References: 85

Abstract

BACKGROUND: Substance use is associated with cardiac disease, and women with HIV have a disproportionately high prevalence of substance use. However, the extent to which ongoing use of multiple substances relates to specific cardiovascular conditions in women with HIV and sociodemographically similar women without HIV ("at risk for HIV") remains understudied. METHODS: We measured left ventricular systolic dysfunction (LVSD) and diastolic dysfunction (LVDD), conditions that precede clinical heart failure, among 1651 participants of the multisite WIHS (Women's Interagency HIV Study). Using standardized echocardiography, we determined associations between the use of substances (stimulants, opioids, tobacco, alcohol, sedatives) reported at ≥2 biannual visits ("sustained use") and left ventricular dysfunction. LVSD was defined as left ventricular ejection fraction

Fields of Study & Subjects

HIV-related health complications and treatments Forensic Toxicology and Drug Analysis Alcohol Consumption and Health Effects

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
5
Pages
e041888–e041888
Publication date
26 February 2026
Language
EN