Deleterious Effects of Liberal Fluid Therapy During Extracorporeal Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest
Abstract
Background During extracorporeal cardiopulmonary resuscitation (ECPR), fluid therapy is often required to maintain adequate blood flow. Here, we aimed to compare the impact of 2 fluid strategies on organ edema, tissue perfusion, and systemic and cerebral hemodynamics in a porcine model of ECPR. Methods Swine were subjected to 15 minutes of ventricular fibrillation followed by 30 minutes of ECPR. After defibrillations and return of spontaneous beating, animals were followed for 120 minutes. Swine were randomly assigned to a conservative group (n=7), in which fluid loading was limited to a maximum of 20 mL/kg per hour of Ringer’s lactate, or a liberal group (n=7), in which fluid loading was allowed as long as right atrial pressure remained
Fields of Study & Subjects
Cardiac Arrest and Resuscitation
Trauma
Hemostasis
Coagulopathy
Resuscitation
Mechanical Circulatory Support Devices
Publication details
- Journal / source
- Journal of the American Heart Association
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 15
- Issue
- 2
- Pages
- e042711–e042711
- Publication date
- 14 January 2026
- Language
- EN