Sex Differences in Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry

Background Spontaneous coronary artery dissection is a cause of myocardial infarction, which predominantly affects middle‐aged women. There are limited data on men with spontaneous coronary artery dissection. Methods Information on demographics, presenting characteristics, in‐hospital outcomes including major adverse cardiovascular events (composite of myocardial infarction, cerebrovascular accident, or heart failure), length of stay, and discharge medications in men and women were obtained from the multicenter iSCAD (International Spontaneous Coronary Artery Dissection) registry. Results Of 1252 patients enrolled from 2019 to 2023, 80 (6.4%) were men. Mean age did not significantly differ between sexes (men, 50.2±10.3 versus women 49.7±10.4; P =0.792). Women reported more emotional stress preceding spontaneous coronary artery dissection (10.2% versus 2.5% men; P =0.025). Men reported more physical stress (22.5% versus 7.7% women; P