PR Interval and the Risks of Recurrent Syncope and All‐Cause Mortality in Patients Presenting With Syncope

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Authors: Asger Knudsen, Johannes J. Struijk, Sam Riahi, Mikkel Porsborg Andersen, Helle Collatz Christensen, Christian Tobias Torp-Pedersen, Kristian Hay Kragholm, Christoffer Polcwiartek, Jørgen K. Kanters, Claus Graff
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References: 36

Abstract

Background Risk assessment of patients with syncope does not consider a short PR interval despite its association with increased risk of atrial fibrillation and all‐cause mortality. This study aimed to explore the association between the PR interval and all‐cause mortality and recurrent syncope in patients admitted to the hospital with syncope. Methods We included patients with a diagnosis of syncope and an ECG recorded within 24 hours of hospital admission from the Danish Nationwide Electrocardiogram Cohort and divided patients into short (200 ms). Patients with ECG abnormalities or comorbidities influencing the PR interval or outcomes were excluded. Results A total of 52 038 patients were included. Adjusting for age, sex, and relevant covariates the highest hazard ratio (HR) was observed in patients with short PR interval with an HR of 1.50 (95% CI, 1.24–1.80, P

Fields of Study & Subjects

Cardiovascular Syncope and Autonomic Disorders Cardiac electrophysiology and arrhythmias Heart Rate Variability and Autonomic Control

Publication details

Journal / source
Journal of the American Heart Association
Volume
15
Issue
4
Pages
e043466–e043466
Publication date
11 February 2026
Language
EN