Amyloidosis in Carpal Tunnel Syndrome and 1‐Year Cardiovascular and Renal Outcomes: A Propensity Score–Matched Cohort Study

Background Carpal tunnel syndrome (CTS) has been recognized as a potential early manifestation of systemic amyloidosis; however, its prognostic implications for cardiovascular and renal outcomes remain unclear. Methods Using the TriNetX global federated research network, we conducted a retrospective cohort study of patients with bilateral CTS between January 2006 and December 2024. Among 221 902 eligible individuals, 2099 had concomitant amyloidosis. After 1:1 propensity score matching for demographics, comorbidities, medications, and laboratory variables, 1957 matched pairs were analyzed. Outcomes included major adverse cardiovascular events, 3‐point major adverse cardiovascular events, heart failure, arrhythmia, dialysis initiation, and major adverse kidney events. Cox proportional hazards models and Kaplan–Meier analyses were performed. Results Compared with patients with CTS and amyloidosis (reference group), those without amyloidosis had significantly lower risks of major adverse cardiovascular events (adjusted hazard ratio [aHR], 0.41 [95% CI, 0.28–0.59]), 3‐point major adverse cardiovascular events (aHR, 0.26 [95% CI, 0.19–0.35]), heart failure (aHR, 0.45 [95% CI, 0.30–0.64]), arrhythmia (aHR, 0.50 [95% CI, 0.35–0.69]), dialysis initiation (aHR, 0.51 [95% CI, 0.37–0.95]), and major adverse kidney events (aHR, 0.28 [95% CI, 0.25–0.99]; all P