Sex Differences in Age of Onset of Premature Cardiovascular Disease and Subtypes: The Coronary Artery Risk Development in Young Adults Study

Journal of the American Heart Association 2026 Open access

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Authors: Alexa A. Freedman, Laura A. Colangelo, Hongyan Ning, Jaclyn D. Borrowman, Cora E. Lewis, Pamela J. Schreiner, Sadiya S. Khan, Donald M. Lloyd‐Jones
DOI: 10.1161/jaha.125.044922
Cited by: 18
References: 26

Abstract

Background Historical data indicate men develop coronary heart disease (CHD) 10 years before women. However, whether this sex gap persists in a contemporary sample amid changing cardiometabolic risk profiles, and whether differences exist for other cardiovascular disease (CVD) subtypes (ie, stroke, heart failure), is not known. Methods Data are from the CARDIA (Coronary Artery Risk Development in Young Adults) study, a prospective multicenter cohort study. US adults aged 18 to 30 years enrolled in 1985 to 1986 and were followed through August 2020. Sex differences in the cumulative incidence functions of premature CVD (onset

Fields of Study & Subjects

Sex and Gender in Healthcare Acute Myocardial Infarction Research Menopause: Health Impacts and Treatments

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
3
Pages
e044922–e044922
Publication date
29 January 2026
Language
EN