Remnant Cholesterol and Atherosclerotic Cardiovascular Disease Risk in Populations With Different Low‐Density Lipoprotein Cholesterol Elevations: A Prospective Cohort Study

Journal of the American Heart Association 2026 Open access

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Authors: H Zheng, Guanlin Chen, Zhenyu Huo, Y Lan, Y Wang, Peng Fu, Weiqiang Wu, Haixiang Zheng, Kuangyi Wu, Z Huang, Dan Wu, S L Wu
+1 more Youren Chen
DOI: 10.1161/jaha.125.045376
Cited by: 3
References: 44

Abstract

BACKGROUND: Low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC) are risk factors for atherosclerotic cardiovascular disease (ASCVD). However, the extent to which differences in RC levels affect ASCVD risk in populations with varying degrees of LDL-C elevation remains unclear. This study aimed to investigate whether RC can provide additional risk stratification value across different sexes, ages, and elevated LDL-C statuses. METHODS: This study included 12 743 elevated LDL-C participants (LDL-C ≥3.4 mmol/L) and 50 073 age- and sex-matched non-elevated LDL-C controls from the Kailuan Study. Elevated LDL-C participants were categorized by RC levels into

Fields of Study & Subjects

Lipoproteins and Cardiovascular Health Diabetes Cardiovascular Risks and Lipoproteins Atherosclerosis and Cardiovascular Diseases

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
4
Pages
e045376–e045376
Publication date
11 February 2026
Language
EN