Long‐Term Impact of Cardiac Resynchronization Therapy by Left Ventricular Septal Pacing

Background Left bundle branch area pacing (LBBAP) is considered to be an alternative modality to deliver cardiac resynchronization therapy (CRT). However, left bundle branch pacing and left ventricular septal pacing (LVSP) are characterized as left bundle branch area pacing. The long‐term effect of only LVSP in patients with a CRT indication is still unknown. Methods Consecutive patients who met the CRT indication were retrospectively included. LVSP was determined during the procedure. New York Heart Association functional class, NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), and echocardiographic and pacing parameters were assessed at implant and follow‐up visit. Results A total of 40 consecutive patients with successful LVSP were included for analysis with a mean follow‐up period of 29.4±16.2 months. The QRS complex in lead V 1 during LVSP featured a QS pattern (52.5%), Qr/qR pattern (30%), or rsR pattern (17.5%). LVSP significantly shortened QRS duration (from baseline 172.5±16.8 to 135.3±19.8 ms, P