Sex‐Based Differences in Patients Undergoing Transcatheter Tricuspid Valve Replacement

he prevalence of significant tricuspid regurgitation (TR) increases with age, with moderate and severe TR affecting up to 1.5% and 5.6% of men and women >70 years of age, respectively.1 Female patients with severe TR undergo surgical intervention less frequently than male patients and often present with higher-risk profiles at the time of treatment.2 Accumulating evidence supports transcatheter tricuspid valve therapies, such as edge-to-edge repair, as alternatives to surgery for significant TR.In patients undergoing transcatheter tricuspid valve intervention, primarily with transcatheter edge-to-edge repair, men appear to have more baseline comorbidities (eg, coronary artery disease), yet sex-based differences in postoperative outcomes such as survival, heart failure rehospitalization, and major complications remain controversial. 1 As transcatheter tricuspid valve replacement (TTVR) has emerged as an alternative option for high-risk patients with TR, this study aims to report sex differences among patients undergoing TTVR.The authors declare that all supporting data are available within the article.A post hoc analysis was performed on patients prospectively enrolled in the first-inhumans confirmatory trial (industry-sponsored, across 11 Chinese centers) and an investigator-initiated trial (conducted at one Chinese center) evaluating the LuX-Valve Plus system (Jenscare Scientific Co., Ltd, China) between May 2022 and March 2024, using identical criteria.Baseline characteristics, intraprocedural details, and short-term follow-up data were compared between male and female patients.All participants provided informed consent, and the study was approved by the institutional review board of each participating center.Statistical analyses used Student's t, Mann-Whitney U, chi-square, and Fisher's exact tests as appropriate, with significance set at P