Air Pollution and Incident Cardiovascular Disease: Modification by Genetic Susceptibility and the Mitigating Role of Physical Activity

Journal of the American Heart Association 2026 Open access

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Authors: Wei Liu, Lin Yu, Meng Yang, Xuefeng Lai, 施达, Hao Wang, Wei Liu, J. J. Song, Xiuqing Cui, W H Chen, Bin Wang
DOI: 10.1161/jaha.125.045919
Cited by: 2
References: 61

Abstract

Background The interplay and joint effects of air pollution, genetic predisposition, and physical activity (PA) on incident cardiovascular disease (CVD) remain poorly understood. This study aimed to examine the associations between various air pollutants and CVD and assessed potential modification by genetic susceptibility and PA. Methods This prospective cohort study included 330 481 UK Biobank participants without baseline CVD. Annual average concentrations of particulate matter

Fields of Study & Subjects

Air Quality and Health Impacts Health Environment Cognitive Aging Genetic Associations and Epidemiology

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
7
Pages
e045919–e045919
Publication date
25 March 2026
Language
EN