Surgical Versus Transcatheter Aortic Valve Replacement in Patients Aged >60 Years With Bicuspid Valve Stenosis: A Time‐to‐Event Data Meta‐Analysis

Background The role of transcatheter aortic valve implantation (TAVI) in bicuspid aortic valve stenosis requires further evaluation, particularly as its use has become comparable to surgical aortic valve replacement. We sought to compare midterm outcomes of TAVI and surgical aortic valve replacement in patients with bicuspid aortic valve stenosis. Methods Systematic searches of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials identified studies reporting TAVI and surgical aortic valve replacement outcomes in patients aged ≥60 years with bicuspid aortic valve stenosis. The primary analysis included only comparative studies with interpretable Kaplan–Meier curves. Individual patient data were reconstructed for time‐to‐event analysis. Sensitivity analyses incorporated noncomparative single‐arm studies. Baseline differences and heterogeneity were addressed using landmark analysis, time‐varying hazard ratios (HRs), frailty Cox models, and covariate‐adjusted restricted mean survival time. The primary outcome was death with or without unplanned rehospitalization and stroke. Results Five comparative, risk‐adjusted studies (TAVI, 5901; surgical aortic valve replacement, 12 427) were included. At 48‐month follow‐up, TAVI was associated with a higher hazard for adverse events (HR, 1.62 [95% CI, 1.46–1.79]; P