Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First‐Pass Outcome in Ischemic Stroke Thrombi

Journal of the American Heart Association 2026 Open access

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Authors: Briana A. Santo, Tatsat R. Patel, Seyyed Sarayi, Kerry E. Poppenberg, Sarah Balghonaim, Alexandria Scotti, TaJania D. Jenkins, Vinay Jaikumar, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Vincent M. Tutino
DOI: 10.1161/jaha.125.046619
Cited by: 2
References: 38

Abstract

BACKGROUND: Radiomic and transcriptomic analyses have independently identified features linked to mechanical thrombectomy (MT) outcomes. Here, we integrated paired radiomics/transcriptomics of stroke clots to identify neutrophil extracellular trap (NET) enrichment as a predictor of first-pass MT success, assessing the potential to noninvasively detect NET enrichment using prethrombectomy computed tomography imaging. METHODS: We performed radiomic/transcriptomic analyses of 32 stroke clots retrieved by MT. Clots were segmented from pre-MT computed tomography angiography and noncontrast computed tomography scans, and radiomic features (RFs) were extracted using PyRadiomics. Differentially expressed genes were identified between modified first-pass effect (mFPE) success and failure using the criteria of log(fold-change) ≥1.5 and q

Fields of Study & Subjects

Neutrophil Myeloperoxidase and Oxidative Mechanisms Acute Ischemic Stroke Management Immune cells in cancer

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
4
Pages
e046619–e046619
Publication date
3 February 2026
Language
EN