Association Between Aortic Valve Mean Gradient and TAVR Outcomes: A Perspective From a Nationwide Registry

Journal of the American Heart Association 2026 Open access

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Authors: Matthew J. Czarny, Maeve Jones‐O’Connor, Rani K. Hasan, Faisal Rahman, Hamza Aziz, Michael P. Robich, Daniel Haugan, Jon R. Resar
DOI: 10.1161/jaha.125.047319
Cited by: 1
References: 34

Abstract

Background Patients with severe aortic stenosis with very low resting aortic valve mean gradient (MG) are underrepresented in transcatheter aortic valve replacement (TAVR) studies. We investigated the association of resting aortic valve MG with post‐TAVR outcomes in a large nationwide cohort. Methods We included patients from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry with a self‐expanding Evolut TAVR (until December 2022) and eligible for 1‐year follow‐up without prior balloon aortic valvuloplasty, TAVR, or surgical aortic valve replacement. Results Among 80 429 patients (mean age, 80.7±7.9; women, 53.9%; high/extreme surgery risk, 51.2%) stratified into 6 echocardiographic resting aortic valve MG groups (10–

Fields of Study & Subjects

Cardiac Valve Diseases and Treatments Congenital Heart Disease Studies Aortic Disease and Treatment Approaches

Publication details

Journal / source
Journal of the American Heart Association
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
19
Pages
e047319–e047319
Publication date
30 August 2026
Language
EN