Abstract A013: Hyperthyroidism: An Overlooked Risk Factor for Cerebral Venous Sinus Thrombosis (CVST) in Women.

Background: Increased pressure and reduced cerebral perfusion in cerebral venous sinus thrombosis can lead to ischemic and hemorrhagic strokes, with up to 15% of patients experiencing long-term disability. CVST accounts for 0.5-3% of strokes, but is responsible for a higher proportion of strokes in younger individuals. Hyperthyroidism has been associated with a prothrombotic, hypofibrinolytic state, with recent studies suggesting higher rates of deep vein thrombosis and pulmonary embolism in people with hyperthyroidism; however, it is still unclear whether hyperthyroidism poses a similar risk for cerebral venous sinus thrombosis. Methods: Using data from Healthcare Cost and Utilization’s Project National Inpatient Sample (NIS) from 2019 to 2022, we identified women aged eighteen to sixty for our cross-sectional analysis. Exposures, outcomes, and covariables of interest were coded using the International Classification of Diseases, Tenth Revision. We used logistic regression with 95% confidence intervals to obtain crude and adjusted models with weighted averages for the association of hyperthyroidism and CVST. Results: A total of 6,780,445 women were included in the study. Women with hyperthyroidism had a twofold higher risk of cerebral venous sinus thrombosis compared to those without hyperthyroidism. These findings remained significant after adjusting for factors such as age, race/ethnicity, pregnancy, hormonal therapy, and comorbidities. In the fully adjusted model, women with hyperthyroidism had 82% higher odds of CVST compared to their counterparts. Conclusion: Hyperthyroidism significantly increased the odds of cerebral venous sinus thrombosis in women. Medical professionals should consider hyperthyroidism as a risk factor for CVST. Effective treatment of this condition may help reduce the risk of venous infarcts in this population.